X chromosome mosaicism

1. Advanced maternal age is associated with X chromosome mosaicism in humans (6-fold).

   “X chromosome mosaicism is the most common karyotypic aberration in women undergoing IVF and has 6-fold increased incidence in AMA women compared to younger ones.”

   Humansundergoing in vitro fertilizationperipheral bloodfemalesn = 1,837

   Female Reproductive Ageing and Chromosomal Abnormalities in a Large Series of Women Undergoing IVF

   Cytogenetic and genome research·Jan 20, 2022

1. inactive X chromosome is associated with X chromosome mosaicism in humans.

   “Methylation array analyses of 33 women with X mosaicism indicate events preferentially involve the inactive X chromosome.”

   Humanswomen with X mosaicismfemalesn = 33

   Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome

   Nature communications·Jun 13, 2016

1. Chronological age is associated with X chromosome mosaicism in humans (0.11% in 50-year olds; 0.45% in 75-year olds).

   “X mosaicism frequency increases with age (0.11% in 50-year olds; 0.45% in 75-year olds)”

   Humansfemalesn = 38,303

   Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome

   Nature communications·Jun 13, 2016

1. X chromosome mosaicism is associated with autosomal mosaic events in humans.

   “participants with X events more likely harbour autosomal mosaic events”

   Humansfemalesn = 38,303

   Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome

   Nature communications·Jun 13, 2016

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