White matter hyperintensity shape

1. White matter hyperintensity shape has no effect on cognitive decline in humans.

   “No associations were found between deep WMH shape and decline in the cognitive domains.”

   Humansdeep WMHbrainfive yearsn = 2,493

   A more irregular shape of white matter hyperintensities is associated with cognitive decline over five years in community-dwelling older adults

   Neurobiology of aging·Apr 1, 2025

1. White matter hyperintensity shape predicts cognitive decline in humans (p < 0.05).

   “A more irregular shape of periventricular/confluent WMH was related to cognitive decline in the memory domain, the executive function domain, and the processing speed domain over five years (p < 0.05).”

   Humansperiventricular/confluent WMHbrainfive yearsn = 2,493

   A more irregular shape of white matter hyperintensities is associated with cognitive decline over five years in community-dwelling older adults

   Neurobiology of aging·Apr 1, 2025

1. White matter hyperintensity shape raises the risk of dementia in humans (HR 1.45, 95% CI 1.32-1.58).

   “More irregular shape of periventricular/confluent WMH (lower solidity (hazard ratio (95% confidence interval) 1.34 (1.17 to 1.52), p < .001) and convexity 1.38 (1.28 to 1.49), p < .001); higher concavity index 1.43 (1.32 to 1.54), p < .001) and fractal dimension 1.45 (1.32 to 1.58), p < .001)”

   Humanscommunity-dwelling older adultsbrainmean follow-up: 9.9 ± 2.6 years

   White matter hyperintensity shape is associated with long-term dementia risk

   Alzheimer's & dementia : the journal of the Alzheimer's Association·Jun 12, 2023

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