Weighted genomic profile score

1. Weighted genomic profile score increases osteoporosis prediction discrimination in humans (AUC from 0.762 (95% CI 0.733–0.800) to 0.786 (0.756–0.823) for FN and 0.785 (0.757–0.824) for LS).

   “The AUC for osteoporosis improved modestly from 0.762”

   Humansinclusion of femoral-neck or lumbar-spine bone mineral density scoresn = 1,750

   Genetic Burden Analyses of Phenotypes Relevant to Aging in the Berlin Aging Study II (BASE-II)

   Gerontology·Jan 29, 2016

1. Weighted genomic profile score has no effect on relative leukocyte telomere length in humans.

   “No significant association was detected for rLTL in either single-SNP or wGPS-based analyses.”

   Humansleukocyten = 1,750

   Genetic Burden Analyses of Phenotypes Relevant to Aging in the Berlin Aging Study II (BASE-II)

   Gerontology·Jan 29, 2016

More on Relative leukocyte telomere length

1. Weighted genomic profile score is associated with body mass index in humans.

   “The trait-specific wGPS was highly significantly associated with BMD (p < 2 × 10-16) and BMI (p = 1.10 × 10-6).”

   Humansn = 1,750

   Genetic Burden Analyses of Phenotypes Relevant to Aging in the Berlin Aging Study II (BASE-II)

   Gerontology·Jan 29, 2016

1. Weighted genomic profile score is associated with bone mineral density in humans.

   “The trait-specific wGPS was highly significantly associated with BMD (p < 2 × 10-16) and BMI (p = 1.10 × 10-6).”

   Humansfemoral neck and lumbar spinen = 1,750

   Genetic Burden Analyses of Phenotypes Relevant to Aging in the Berlin Aging Study II (BASE-II)

   Gerontology·Jan 29, 2016