Ventricular-brain ratio

1. Alzheimer's disease pathology severity has no effect on ventricular-brain ratio in humans.

   “VBR did not differ significantly according to the severity of AD pathology in elderly patients with schizophrenia.”

   Humansschizophrenia with onset age <40 yearsbrainn = 31

   Exploring the neuropathological basis of lateral ventricular enlargement in elderly patients with schizophrenia

   Psychiatry and clinical neurosciences·May 28, 2026

1. Illness duration is associated with ventricular-brain ratio in humans.

   “In elderly schizophrenia patients without neurodegenerative diseases, VBR was significantly correlated with illness duration but not with age at computed tomography scanning.”

   Humansschizophrenia without neurodegenerative diseasesbrain

   Exploring the neuropathological basis of lateral ventricular enlargement in elderly patients with schizophrenia

   Psychiatry and clinical neurosciences·May 28, 2026

1. Aging-related tau astrogliopathy is associated with ventricular-brain ratio in humans.

   “patients with aging-related tau astrogliopathy (ARTAG) in the medial temporal lobe exhibited a significantly higher VBR than those without.”

   Humansschizophrenia; compared with patients without aging-related tau astrogliopathymedial temporal lobe

   Exploring the neuropathological basis of lateral ventricular enlargement in elderly patients with schizophrenia

   Psychiatry and clinical neurosciences·May 28, 2026

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