Vascular health composite score

1. Vascular health composite score has no effect on cognitive functioning composite score in humans.

   “No direct pathways were found between lifestyle and brain health, or between vascular health and cognitive functioning.”

   Humanswith modifiable risk of cognitive declinen = 176

   Integrating lifestyle, vascular, brain and cognitive markers: an exploratory multimodal approach to brain aging

   medRxiv·Jan 9, 2026Preprint

1. Vascular health composite score is associated with MRI-based brain health composite score in humans (β = 0.18, p = 0.01).

   “and vascular and brain health (β = 0.18, p = 0.01).”

   Humanswith modifiable risk of cognitive declinen = 176

   Integrating lifestyle, vascular, brain and cognitive markers: an exploratory multimodal approach to brain aging

   medRxiv·Jan 9, 2026Preprint

More on MRI-based brain health composite score

1. Lifestyle is associated with vascular health composite score in humans (β = 0.23, p = 0.002).

   “SEM showed associations between lifestyle and vascular health (β = 0.23, p = 0.002)”

   Humanswith modifiable risk of cognitive declinen = 176

   Integrating lifestyle, vascular, brain and cognitive markers: an exploratory multimodal approach to brain aging

   medRxiv·Jan 9, 2026Preprint

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