Vaccine-induced spike-specific CD4+ T cells

Older age is associated with vaccine-induced spike-specific CD4+ T cells in humans.

“older adults (aged ≥65 years) had fewer vaccine-induced spike-specific CD4+ T cells”

Humanscompared with younger adultsfirst dosen = 216

Impaired CD4⁺ T cell response in older adults is associated with reduced immunogenicity and reactogenicity of mRNA COVID-19 vaccination

Nature aging·Jan 12, 2023