Truncated proteoform of AP2B1

female sex and advanced age is associated with truncated proteoform of AP2B1 in zebrafish.

“we identified a truncated proteoform of AP2B1, a subunit of the AP2 adaptor complex closely associated with clathrin-mediated endocytosis and cellular aging, in female zebrafish aged 24 months exclusively”

Animalsbrainfemales

Top-Down Proteomics Study of Aging and Sexual Dimorphism of Zebrafish Brains

Journal of mass spectrometry : JMS·Dec 30, 2025