Total polyubiquitinated proteins

1. Vitellogenin increases total polyubiquitinated proteins in worms.

   “gonadally accumulating vitellogenin proteins substantially contributed to the total polyubiquitinated proteins observed during aging.”

   Model organismsgonad

   Validation of tissue-specific RNAi systems in C. elegans reveals a converging role for polyubiquitin UBQ-1/UBC in vitellogenin metabolism and lifespan

   bioRxiv (Cold Spring Harbor Laboratory)·23 Feb 2026Preprint

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