What does the research say about Total polyamine content?

Total polyamine content

There are 2 papers on total polyamine content in aging research: 1 observational study in people, 1 in animals. The newest story, Oct 31, 2026: “Cell chemistry shifts with age in Syrian hamster testes”.

Biomarker

2 papers study it2 findings

See all 2

“The total content of polyamines is significantly lower in groups 2 and 3 compared to group 1 (p=3.6×10(-12)).”

Spermidine and spermine are enriched in whole blood of nona/centenariansRejuvenation research2012doi:10.1089/rej.2012.1349

Humans1
Animals1

Upstream

Aged testes

upin M. auratus1

1 study

Aged testes increase total polyamine content in M. auratus with age.
“At the tissue level, total PA concentration increased with age.”
Animalswith agetestis
Cell chemistry shifts with age in Syrian hamster testes
BiologyJul 17, 2026

Associations

Chronological age

downin humans1

1 study

Chronological age is associated with total polyamine content in humans (compared with group 1 (31-56 years)).
“The total content of polyamines is significantly lower in groups 2 and 3 compared to group 1 (p=3.6×10(-12)).”
Humanscompared with group 1 (31-56 years)whole bloodn = 78
Spermidine and spermine are enriched in whole blood of nona/centenarians
Rejuvenation researchNov 16, 2012

Latest

1 paper in 12 months

BiologyJul 28

Cell chemistry shifts with age in Syrian hamster testes

An animal experiment compared three age groups and five testicular cell types, finding patterns that suggested increased breakdown of small molecules called polyamines.An animal experiment compared three age groups and five testicular cell types, finding patterns that suggested increased breakdown of small molecules called polyamines.

Animal studyReproductive system

Paper

Rejuvenation ResearchNov 16

Spermidine and spermine are enriched in whole blood of nona/centenarians

Cross-sectional study of 78 peopleMechanisms