TOMM40 and APOE expression

TOMM40 '523' polyT variant is associated with TOMM40 and APOE expression in mice.

“Noteworthy, the regulatory effect of the '523' polyT genotype was observed for all studied organs.”

Animalsbrain, liver, and spleen

The APOE-TOMM40 Humanized Mouse Model: Characterization of Age, Sex, and PolyT Variant Effects on Gene Expression

Journal of Alzheimer's disease : JAD·Jan 1, 2023