Tissue-corrected excitatory-inhibitory balance

1. Anterior-to-posterior cerebral blood flow gradient has no effect on tissue-corrected excitatory-inhibitory balance in humans.

   “we found no relationship between neural dedifferentiation, as indicated by the CBF gradient, and synaptic scaling (EIB)”

   Humanshealthy agingpresupplementary motor area

   CBF gradient and excitatory-inhibitory balance measured from pre-SMA - importance in aging and semantic fluency task difficulties

   NeuroImage·11 Sep 2025

More on Anterior-to-posterior cerebral blood flow gradient

1. Tissue-corrected excitatory-inhibitory balance is associated with semantic fluency task difficulty in humans.

   “The tissue-corrected EIB exhibited a positive relationship with the difficulty of the semantic fluency task.”

   Humanshealthy agingpresupplementary motor area

   CBF gradient and excitatory-inhibitory balance measured from pre-SMA - importance in aging and semantic fluency task difficulties

   NeuroImage·11 Sep 2025

1. Older age is associated with tissue-corrected excitatory-inhibitory balance in humans.

   “Older participants exhibited a stronger inhibitory tone in the pre-SMA, driven by reduced tissue-corrected Glx in the older cohort.”

   HumansGABA+/Glx ratio; healthy agingpresupplementary motor area

   CBF gradient and excitatory-inhibitory balance measured from pre-SMA - importance in aging and semantic fluency task difficulties

   NeuroImage·11 Sep 2025