Thin spine proportion

Age is associated with thin spine proportion in mice.

“Morphological assessment of spines indicated age-dependent changes, including a notable increase in the proportion of thin spines in the CA1 and PFC regions.”

Animalshippocampal CA1 and prefrontal cortexmales

Dendritic spine degeneration is associated with age-related decline in recognition and spatial memory in male mice

Brain structure & function·28 Aug 2025