What does the research say about target expression?

Target expression

There is 1 paper on target expression in aging research: none in people yet, 1 in animals. The newest story, Nov 13, 2026: “RNA platform sustained gene silencing beyond the liver in mice”.

Biomarker

1 paper studies it28 more mention it1 finding

1 new paper in 30 daysSee all 29 papers on target expression

Animals1

Interventions

Lico

downin mice1

1 study

Lico decreases target expression in mice (>90% target knockdown; ≥50% silencing for 6 months; measurable activity at 9 months).
“A single systemic dose in mice produced >90% target knockdown in skeletal muscle, heart, aorta, and adipose tissue”
Animalsskeletal muscle, heart, aorta, and adipose tissueA single systemic doseUp to 9 months
RNA platform sustained gene silencing beyond the liver in mice
Molecular therapy. Nucleic acidsOct 21, 2026

Latest

4 papers in 12 months

Molecular Therapy Nucleic AcidsNov 13

RNA platform sustained gene silencing beyond the liver in mice

One dose reduced target gene messages by more than 90% in several mouse tissues, with at least 50% silencing lasting six months.One dose reduced target gene messages by more than 90% in several mouse tissues, with at least 50% silencing lasting six months.

Mouse studyInterventions