Synaptic pGluN2B proportion

Biomarker

1 paper studies it2 findings

  • Animals1

Interventions

1

Estradiol

downin rhesus monkeys1

1 study
  1. Estradiol decreases synaptic pGluN2B proportion in rhesus monkeys.

    “the percentage of gold particles located within the synaptic compartment was significantly lower in aged-E monkeys compared to young-E and aged-V monkeys.”

    Animalsovariectomized monkeys; compared with aged vehicle-treated monkeysdorsolateral prefrontal cortexlong-termfemales

    Estrogen Alters the Synaptic Distribution of Phospho-GluN2B in the Dorsolateral Prefrontal Cortex While Promoting Working Memory in Aged Rhesus Monkeys

    Neuroscience

More on Estradiol

Associations

1

Working memory accuracy

downin rhesus monkeys1

1 study
  1. Synaptic pGluN2B proportion is associated with working memory accuracy in rhesus monkeys.

    “In aged monkeys, DR average accuracy inversely correlated with the percentage of synaptic pGluN2B”

    Animalsovariectomized monkeys; delayed response testdorsolateral prefrontal cortexfemales

    Estrogen Alters the Synaptic Distribution of Phospho-GluN2B in the Dorsolateral Prefrontal Cortex While Promoting Working Memory in Aged Rhesus Monkeys

    Neuroscience

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