Structure model index

There are 9 papers on structure model index in aging research: 3 observational studies in people, 5 in animals.

9 papers study it10 more mention it2 findings

See all 19 papers on structure model index

“after adjusted for covariance, asymptomatic VF showed significantly lower trabecular vBMD (Tb.vBMD) at radius but higher SMI at tibia”

Performance of HR-pQCT, DXA, and FRAX in the discrimination of asymptomatic vertebral fracture in postmenopausal Chinese womenArchives of osteoporosis2021doi:10.1007/s11657-021-00939-0

Humans3
Animals5

Interventions

1

Caloric restriction

downin mice1

1 study

Caloric restriction decreases structure model index in mice (40% food restriction).
“In parallel, lifelong CR groups showed reduced structure model index values compared to age-matched controls indicating a transformation of vertebral trabecular bone microarchitecture toward a platelike geometry.”
Animals40% food restrictionlumbar vertebrae
Dietary Restriction-Induced Alterations in Bone Phenotype: Effects of Lifelong Versus Short-Term Caloric Restriction on Femoral and Vertebral Bone in C57BL/6 Mice
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral ResearchDec 28, 2015

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Associations

1

Asymptomatic vertebral fracture

upin humans1

1 study

Asymptomatic vertebral fracture is associated with structure model index in humans (adjusted for covariance).
“after adjusted for covariance, asymptomatic VF showed significantly lower trabecular vBMD (Tb.vBMD) at radius but higher SMI at tibia”
Humansadjusted for covariancetibiafemalesn = 175
Performance of HR-pQCT, DXA, and FRAX in the discrimination of asymptomatic vertebral fracture in postmenopausal Chinese women
Archives of osteoporosisSep 4, 2021

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Latest

3 papers in 12 months

International Journal of EndocrinologyMar 6

Effects of Glucagon-Like Peptide-1 Receptor Agonist on Bone Metabolism and the Expression of Insulin Receptor Substrate 1 in an Osteoporotic Rat Model

Experiments in 18 ratsGLP-1 receptor agonists

Lishizhen Medicine and Materia Medica ResearchFeb 1

Research on the effect of Fructus Lycii Ruthenic and Herba Cistanches on senile osteoporosis in aged rats via regulation of the PI3K/Akt signaling pathway

Experiments in 48 ratsBones and joints

JBMR PlusNov 27

Serum-derived exosomes of young rats protect bone of ovariectomized rats after fatigue loading in vivo

Experiments in ratsBones and joints

Bone ReportsAug 14

Trabecular bone deterioration in a postmenopausal female suffering multiple spontaneous vertebral fractures due to a delayed denosumab injection - A post-treatment re-initiation bone biopsy-based case study

Case reportDenosumab

NutrientsSep 24

Combination of Caloric Restriction and a Mixed Training Protocol as an Effective Strategy to Counteract the Deleterious Effects in Trabecular Bone Microarchitecture Caused by a Diet-Induced Obesity in Sprague Dawley Rats

Experiments in 88 ratsDietary restriction

Archives of OsteoporosisSep 5

Performance of HR-pQCT, DXA, and FRAX in the discrimination of asymptomatic vertebral fracture in postmenopausal Chinese women

Case-control study of 175 peopleBiomarkers

Journal of Bone and Mineral MetabolismJun 11

Deterioration of bone microstructure by aging and menopause in Japanese healthy women: analysis by HR-pQCT

Cross-sectional study of 61 peopleBiomarkers

Journal of the Mechanical Behavior of Biomedical MaterialsJul 9

Pore network microarchitecture influences human cortical bone elasticity during growth and aging

Cross-sectional study of 16 peopleBones and joints

Journal of Bone and Mineral ResearchDec 28

Dietary Restriction-Induced Alterations in Bone Phenotype: Effects of Lifelong Versus Short-Term Caloric Restriction on Femoral and Vertebral Bone in C57BL/6 Mice

Experiments in miceDietary restriction

Calcified Tissue InternationalSep 16

Sigma Anti-bonding Calcium Attenuates Ovariectomy-Induced Bone Loss by Preserving Trabecular Microarchitecture and Suppressing Osteoclastogenesis

Experiments in miceBones and joints

See all 19 papers on structure model index