Striatal dopamine D2-receptor availability
1 paper2 findings
- Humans1
Upstream
1Healthy aging
downin humans1−5% per decade
1 study
Healthy aging
downin humans1−5% per decade
Healthy aging decreases striatal dopamine D2-receptor availability in humans (approximately -5% per decade).
“striatal dopamine D2-receptor availability (approximately -5% per decade)”
Humansstriatum10 yearsn = 181
Cerebral cortex (New York, N.Y. : 1991)1 Nov 2025
Associations
1General cognition
upin humans1
1 study
General cognition
upin humans1
Striatal dopamine D2-receptor availability is associated with general cognition in humans (r = 0.31).
“Changes in dopamine D2-receptor and a factor of general cognition were positively correlated (r = 0.31, P(r > 0.00) > 0.95).”
Humansstriatum10 yearsn = 93
Cerebral cortex (New York, N.Y. : 1991)1 Nov 2025
Latest
1 in 12 monthsCerebral Cortex
10-year longitudinal dopamine D2-receptor losses are associated with cognitive decline in healthy aging
Cohort study of 181 peopleMechanisms