Speech composite score

1. Speech composite score is associated with cognitive function in humans (Spearman rho |0.21-0.49|).

   “All three composites were significantly and similarly correlated with clinical endpoints at baseline (Spearman rho ranging from |0.21‐0.49|).”

   Human trialAlzheimer's disease test set at baselinen = 227

   Development and validation of speech‐based biomarkers for measuring clinical progression in AD clinical trials

   AAIC 2025 abstract·26 Dec 2025

1. Speech composite score is associated with Mini-Mental State Examination in humans (-0.46 <= r <= -0.26).

   “In all four languages, significant correlations with the MMSE were found with both the composite score (‐0.46 ≤ r ≤ ‐0.26) and the object content score (0.27 ≤ r ≤ 0.42).”

   Human trialMCI or mild AD patients across Danish, German, Dutch, and Spanishn = 244

   Generalizability of digital speech and language assessments in MCI/mild AD across four non‐English languages

   AAIC 2025 abstract·23 Dec 2025

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