1 paper2 findings
Early cognitive function
no changein humans1
Severe enlarged centrum semiovale perivascular spaces have no effect on early cognitive function in humans.
HumansAmyloid-positive, cognitively unimpaired, hemorrhage-free older adults61.3% femalesn = 932
Severely enlarged brain vessel spaces predicted bleeding lesions
Annals of neurology9 Oct 2026
First CAA-related hemorrhagic lesions
upin humans1HR 2.85
Severe enlarged centrum semiovale perivascular spaces predict first CAA-related hemorrhagic lesions in humans (33.7% versus 13.6%; adjusted HR 2.85, 95% CI 1.91–4.25).
HumansAmyloid-positive, cognitively unimpaired, hemorrhage-free older adults; severe versus nonsevere EPVS-CSObrainMedian follow-up 5.1 years61.3% femalesn = 932
Severely enlarged brain vessel spaces predicted bleeding lesions
Annals of neurology9 Oct 2026
Over a median 5.1 years, bleeding-related lesions appeared in 33.7% of participants with severe enlargement versus 13.6% without severe enlargement.Over a median 5.1 years, bleeding-related lesions appeared in 33.7% of participants with severe enlargement versus 13.6% without severe enlargement.