Sen-Age

1. Cancer increases Sen-Age in humans (adj mean: -0.44 vs -0.83).

   “Moreover, cancer survivors have higher Sen-Age score (adj mean: -0.44 ) than non-cancer controls (adj mean: -0.83).”

   Humanscancer survivors compared to non-cancer controlsblood

   SenMayo Based Aging Signature (Sen-Age) in cancer survivors: The Health and Retirement Study (HRS) · GSA 2025 abstract · 31 Dec 2025

Cancer →

1. Sen-Age is associated with mortality in humans (HR: 1.47 [1.17–1.85] per 1 year).

   “Sen-Age was associated with increased risk of mortality in cancer survivors (HR: 1.47 [1.17–1.85] per 1 year, p = 0.0008).”

   Humansin cancer survivors, adjusted for age, sex, and raceblood4-yearn = 609

   SenMayo Based Aging Signature (Sen-Age) in cancer survivors: The Health and Retirement Study (HRS) · GSA 2025 abstract · 31 Dec 2025