SEACpG

1. Smoking increases SEACpG in humans (P < 0.05).

   “Current smokers also displayed advanced SEACpG (P < 0.05).”

   Humansmales

   Sperm epigenetic clock associates with pregnancy outcomes in the general population

   Human reproduction (Oxford, England)·May 14, 2022

More on Smoking

1. SEACpG decreases gestational age in humans (-2.13 days, 95% CI -3.67 to -0.59).

   “advanced SEACpG was associated with shorter gestational age (n = 192; -2.13 days; 95% CI: -3.67, -0.59; P = 0.007).”

   Humansmalesn = 192

   Sperm epigenetic clock associates with pregnancy outcomes in the general population

   Human reproduction (Oxford, England)·May 14, 2022

1. SEACpG decreases fecundability in humans (FOR 0.83, 95% CI 0.76-0.90).

   “In adjusted discrete Cox models, SEACpG was negatively associated with TTP (fecundability odds ratios (FORs)=0.83; 95% CI: 0.76, 0.90; P = 1.2×10-5)”

   Humans12 monthsmalesn = 379

   Sperm epigenetic clock associates with pregnancy outcomes in the general population

   Human reproduction (Oxford, England)·May 14, 2022