RIPK1 activation

1. Diabetes mellitus is associated with RIPK1 activation in humans.

   “we demonstrate a decrease in spermidine and activation of RIPK1 in the vascular tissues of human patients with diabetes.”

   Humanspatients with diabetesvascular tissue

   Spermidine mediates acetylhypusination of RIPK1 to suppress diabetes onset and progression

   Nature cell biology·7 Nov 2024

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