What does the research say about QRISK4-Lifetime?

QRISK4-Lifetime

There is 1 paper on QRISK4-Lifetime in aging research: 1 observational study in people. The newest story, Nov 10, 2026: “Lifetime risk model matched standard 10-year prediction accuracy”.

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1 paper studies it2 findings

1 new paper in 30 daysSee all 1 papers on QRISK4-Lifetime

“Lifetime assessment identified a substantially younger population with increased lifetime risks but below the specified 10-year threshold of 10%”

Development and 10-year validation of QRISK4-Lifetime for cardiovascular risk prediction in 13 million adultsmedRxiv2026doi:10.64898/2026.11.07.26367485

Humans1

Associations

Selection of younger patients with increased lifetime cardiovascular disease risk

mixedin humans1

1 study

QRISK4-Lifetime is associated with selection of younger patients with increased lifetime cardiovascular disease risk in humans (patients meeting only the lifetime threshold, below the 10-year risk threshold of 10%) (262,417 patients (8.1% of the cohort) met only the lifetime threshold).
“Lifetime assessment identified a substantially younger population with increased lifetime risks but below the specified 10-year threshold of 10%”
Humanspatients meeting only the lifetime threshold, below the 10-year risk threshold of 10%lifetime to age 9579.5% were mensn = 262,417
Lifetime risk model matched standard 10-year prediction accuracy
medRxivNov 9, 2026Preprint

10-year cardiovascular disease risk

no changein humans1

1 study

QRISK4-Lifetime predicts 10-year cardiovascular disease risk in humans (validation cohort; comparison with QRISK4) (C-index 0.860 (95% CI 0.858–0.862) in women and 0.845 (0.843–0.847) in men for both models).
“QRISK4-Lifetime had similar performance to QRISK4 when evaluated at 10 years.”
Humansvalidation cohort; comparison with QRISK410 years
Lifetime risk model matched standard 10-year prediction accuracy
medRxivNov 9, 2026Preprint

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1 paper in 12 months

medRxivNov 10

Lifetime risk model matched standard 10-year prediction accuracy

Both models scored 0.860 in women and 0.845 in men for distinguishing who developed cardiovascular disease over 10 years.Both models scored 0.860 in women and 0.845 in men for distinguishing who developed cardiovascular disease over 10 years.

Preprint: cohort · 3,246,602 peopleBiomarkers

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QRISK4-Lifetime

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Lifetime risk model matched standard 10-year prediction accuracy

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