There are 8 papers on psoas muscle volume in aging research: 1 trial and 5 observational studies in people, 2 reviews.
8 papers study it14 more mention it4 findings
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“PV showed strong correlations with ASM indices, particularly the PV/BMI index, which demonstrated the highest diagnostic accuracy.”
- Human trial1
- Humans5
Interventions
2Semaglutide
downin humans1
1 study
Semaglutide
downin humans1
Semaglutide decreases psoas muscle volume in humans (single-arm study in people with HIV and MASLD) (-9.3% (95% CI -13.4 to -5.2)).
“Psoas muscle volume decreased by 9.3% (95% confidence interval [CI]: -13.4 to -5.2; P < .001) over 24 weeks”
Human trialsingle-arm study in people with HIV and MASLDpsoas muscletitrated to 1 mg/week24 weeksn = 46
Effects of Semaglutide on Muscle Structure and Function in the SLIM LIVER Study
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Sodium zirconium cyclosilicate
upin humans1
1 study
Sodium zirconium cyclosilicate
upin humans1
Sodium zirconium cyclosilicate improves psoas muscle volume in humans (chronic hyperkalemia) (p < 0.05).
“Psoas muscle volume and average days for one movement also improved significantly during the therapeutic period (p < 0.05 for both).”
Human trialchronic hyperkalemia3 monthsn = 24
Impact of Sodium Zirconium Cyclosilicate Therapy on Nutrition Status in Patients with Hyperkalemia
Journal of clinical medicine
Associations
230-day mortality
downin humans1HR 0.57
1 study
30-day mortality
downin humans1HR 0.57
Psoas muscle volume is associated with 30-day mortality in humans (Patients undergoing transcatheter aortic valve implantation; association beyond STS score) (HR 0.57, 95% CI 0.36–0.89).
“lower psoas muscle volume was associated with increased 30-day mortality beyond STS (hazard ratio [HR]=0.57, 95%CI 0.36–0.89; p=0.013)”
HumansPatients undergoing transcatheter aortic valve implantation; association beyond STS scorepsoas muscle30 days42.3% femalesn = 1,418
ESC Congress 2026 abstract
Appendicular skeletal muscle mass index
upin humans1
1 study
Appendicular skeletal muscle mass index
upin humans1
Psoas muscle volume is associated with appendicular skeletal muscle mass index in humans.
“PV showed strong correlations with ASM indices, particularly the PV/BMI index, which demonstrated the highest diagnostic accuracy.”
Humansn = 3,999
Aging clinical and experimental research