Polygenic scores for repeat instability

Polygenic scores for repeat instability is associated with somatic DNA-repeat expansion rate in humans (Fourfold variation between highest and lowest 5% of polygenic scores).

“at one repeat, somatic expansion rates varied fourfold between individuals with the highest and lowest 5% of polygenic scores.”

HumansAt one repeat; highest versus lowest 5% of polygenic scoresblood

Insights into DNA repeat expansions among 900,000 biobank participants

Nature·7 Jan 2026