1 paper mentions it2 findings
See all 1 papers on polygenic score combining the effects of ADRD loci other than APOE
“Individuals in the tenth decile of the score exhibited a twofold increased risk of presenting with Braak neurofibrillary tangles stage of >4”
Associations
2Moderate-to-severe neuritic amyloid plaque pathology
upin humans1
1 study
Moderate-to-severe neuritic amyloid plaque pathology
upin humans1
Polygenic score combining the effects of ADRD loci other than APOE is linked with a higher risk of moderate-to-severe neuritic amyloid plaque pathology in humans (excluding APOE loci, comparing tenth decile to median score group) (twofold increased risk).
“moderate-to-severe neuritic amyloid plaque pathology at death compared to individuals in the median score group.”
Humansexcluding APOE loci, comparing tenth decile to median score group
Nature genetics
More on Moderate-to-severe neuritic amyloid plaque pathology
Braak neurofibrillary tangles stage >4
upin humans1
1 study
Braak neurofibrillary tangles stage >4
upin humans1
Polygenic score combining the effects of ADRD loci other than APOE is linked with a higher risk of Braak neurofibrillary tangles stage >4 in humans (excluding APOE loci, comparing tenth decile to median score group) (twofold increased risk).
“Individuals in the tenth decile of the score exhibited a twofold increased risk of presenting with Braak neurofibrillary tangles stage of >4”
Humansexcluding APOE loci, comparing tenth decile to median score group
Nature genetics