Phospho-tau-positive aggregates

1 paper1 finding

Animals1

Upstream

1

TP73

downin mice1

1 study

TP73 protects against phospho-tau-positive aggregates in mice.
“Haploinsufficiency for the p53 family member p73 causes behavioral and neuroanatomical correlates of neurodegeneration in aging mice, including the appearance of aberrant phospho-tau-positive aggregates.”
Animalshaploinsufficiency (p73+/-)brain
p73 haploinsufficiency causes tau hyperphosphorylation and tau kinase dysregulation in mouse models of aging and Alzheimer's disease
Neurobiology of agingMay 15, 2012

Latest

Neurobiology of AgingMay 15

p73 haploinsufficiency causes tau hyperphosphorylation and tau kinase dysregulation in mouse models of aging and Alzheimer's disease

Experiments in miceMechanisms