PC-Horvath2

Biomarker1 paper1 finding

Human trial1

Interventions

1

Metformin

downin humans1

1 study

Metformin decreases PC-Horvath2 in humans (-0.40±0.16 per year).
Human trialglucose intolerancetwo yearsn = 145
A Randomized Clinical Trial of Metformin to Reduce Frailty in Older Adults with Glucose Intolerance · medRxiv : the preprint server for health sciences · 28 Jul 2026 · Preprint

Latest

1

medRxivHuman trialPreprint20 Aug

A Randomized Clinical Trial of Metformin to Reduce Frailty in Older Adults with Glucose Intolerance