Pace of organ aging

1. Pace of organ aging is associated with cortical thickness in humans (ß=-0.02 SD, q<0.05).

   “Independent of their respective late‐life age gaps, faster pace of immune and pancreas aging was associated with lower total cortical thickness (ß=‐0.02 SD, q<0.05) and temporal‐parietal volume”

   Humansimmune aging pace, independent of late-life age gapn = 3,725

   Plasma protein‐based organ age gap and pace of organ aging were associated with incident dementia and brain structures · AAIC 2025 abstract · 25 Dec 2025

1. Pace of organ aging raises the risk of dementia in humans (HR=1.04-1.05, q<0.05).

   “Faster paces of aging in brain, heart, intestine, muscle, and pancreas were associated with higher dementia risk independent of their respective late‐life organ age gaps (HR=1.04‐1.05, q<0.05”

   Humansfaster paces in brain, heart, intestine, muscle, and pancreas7 yearsn = 3,725

   Plasma protein‐based organ age gap and pace of organ aging were associated with incident dementia and brain structures · AAIC 2025 abstract · 25 Dec 2025

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