PACAP

1 paper1 finding

Humans1

Associations

1

Alzheimer's disease

downin silico1OR 0.87

1 study

PACAP lowers the risk of Alzheimer's disease in silico (OR 0.87, 95% CI 0.79–0.95).
“genetically proxied higher blood PACAP levels were causally linked to a decreased risk of AD (OR=0.87, 95%CI=0.79‐0.95, p = 0.003)”
In silicotwo-sample Mendelian randomization
Higher blood pituitary adenylate cyclase‐activating polypeptide levels were causally associated with a decreased risk of Alzheimer's disease
AAIC 2025 abstract24 Dec 2025

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AAIC 2025 Abstract24 Dec

Higher blood pituitary adenylate cyclase‐activating polypeptide levels were causally associated with a decreased risk of Alzheimer's disease

Mendelian randomisation in 63,926 peopleMechanisms