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Open-angle glaucoma polygenic risk score

There is 1 paper on open-angle glaucoma polygenic risk score in aging research: 1 observational study in people. The newest story, Nov 12, 2026: “Updated genetic score improves glaucoma risk prediction”.

Biomarker

1 paper studies it5 findings

1 new paper in 30 daysSee all 1 papers on open-angle glaucoma polygenic risk score

“those in the top 10% of the PRS distribution had a 10-fold increased risk of OAG compared with the remainder”
Step change in glaucoma polygenic risk score performance enables clinical utilityOphthalmology2026doi:10.1016/j.ophtha.2026.10.013
  • Humans1

Associations

4

Open-angle glaucoma

upin humans1OR 10.04

1 study

  1. Open-angle glaucoma polygenic risk score predicts open-angle glaucoma in humans (Risk among first-degree relatives).

    “The PRS also predicted treatment escalation in early disease, prevalent and incident glaucoma surgery, and OAG risk among first-degree relatives.”

    HumansRisk among first-degree relatives

    Updated genetic score improves glaucoma risk prediction

    Ophthalmology

  2. Open-angle glaucoma polygenic risk score is associated with open-angle glaucoma in humans (Australian individuals of European ancestry; highest PRS decile versus the remainder) (OR 10.04, 95% CI 7.43–13.59).

    “those in the top 10% of the PRS distribution had a 10-fold increased risk of OAG compared with the remainder”

    HumansAustralian individuals of European ancestry; highest PRS decile versus the remainder

    Updated genetic score improves glaucoma risk prediction

    Ophthalmology

More on Open-angle glaucoma

Glaucoma surgery

upin humans1

1 study

  1. Open-angle glaucoma polygenic risk score predicts glaucoma surgery in humans (Prevalent and incident surgery).

    “The PRS also predicted treatment escalation in early disease, prevalent and incident glaucoma surgery”

    HumansPrevalent and incident surgery

    Updated genetic score improves glaucoma risk prediction

    Ophthalmology

Treatment escalation

upin humans1

1 study

  1. Open-angle glaucoma polygenic risk score predicts treatment escalation in humans (Early open-angle glaucoma).

    “The PRS also predicted treatment escalation in early disease”

    HumansEarly open-angle glaucoma

    Updated genetic score improves glaucoma risk prediction

    Ophthalmology

Age at glaucoma onset

downin humans1

1 study

  1. Open-angle glaucoma polygenic risk score is associated with age at glaucoma onset in humans (Highest-risk PRS decile versus lowest decile) (Approximately 25 years earlier onset).

    “On average, individuals in the highest-risk decile developed glaucoma approximately 25 years earlier than those in the lowest decile”

    HumansHighest-risk PRS decile versus lowest decile

    Updated genetic score improves glaucoma risk prediction

    Ophthalmology

Latest

Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 0Nov 2026: 11 paper in 12 months
Ophthalmology

Updated genetic score improves glaucoma risk prediction

Australians of European ancestry in the score’s top 10% had 10.04 times the odds of glaucoma compared with the remaining participants.Australians of European ancestry in the score’s top 10% had 10.04 times the odds of glaucoma compared with the remaining participants.

Genetic association studyOpen-angle glaucoma
Paper

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