Nicotine binding site density

1. Alzheimer's disease is associated with nicotine binding site density in humans (50% reduction).

   “Samples of infratemporal cortex (Brodmann area 38) from patients with Alzheimer's disease had a 50% reduction in the number of L-[3H]nicotine sites.”

   Humanscompared with controlsinfratemporal cortex, Brodmann area 38

   Characterization of L-[3H]nicotine binding in human cerebral cortex: comparison between Alzheimer's disease and the normal

   Journal of neurochemistry·1 Dec 1986

More on Alzheimer's disease

1. Age is associated with nicotine binding site density in humans.

   “In human cortical membranes, binding site density decreased with normal aging.”

   Humansnormal agingcerebral cortex

   Characterization of L-[3H]nicotine binding in human cerebral cortex: comparison between Alzheimer's disease and the normal

   Journal of neurochemistry·1 Dec 1986