Neocortical tau-PET accumulation

Tau accumulation status is associated with neocortical tau-PET accumulation in humans (all p <0.001).

“Tau-accumulators showed significantly greater tau-PET at baseline and accumulation in regions not included in Braak I-IV (all p <0.001).”

Humansin amyloid-beta negative cognitively unimpaired individualsbrainn = 333

Longitudinal tau‐PET accumulation and downstream effects in amyloid‐beta negative cognitively unimpaired individuals

AAIC 2025 abstract·7 Jan 2026