Multiple driver mutations

Biomarker

4 papers mention it1 finding

1 new paper in 30 daysSee all 4 papers on multiple driver mutations

“multiple further driver mutations that confer selective advantages up to 100-fold larger than the early drivers.”

Evolutionary dynamics in the years preceding acute myeloid leukaemiaNature2026doi:10.1038/s41586-026-11269-x

Effects

Clonal selective advantage

upin humans1

1 study

Multiple driver mutations are linked with higher clonal selective advantage in humans (Pre-diagnostic acute myeloid leukemia) (Selective advantages up to 100-fold larger than early drivers).
“multiple further driver mutations that confer selective advantages up to 100-fold larger than the early drivers.”
HumansPre-diagnostic acute myeloid leukemiablood
Blood cell takeovers linked to future acute myeloid leukemia
NatureNov 11, 2026

Latest

2 papers in 12 months

NatureNov 11

Blood cell takeovers linked to future acute myeloid leukemia

Later cancer-promoting mutations were linked to growth advantages up to 100-fold larger than those of early mutations in blood cell families.Later cancer-promoting mutations were linked to growth advantages up to 100-fold larger than those of early mutations in blood cell families.

Cohort · 420,054 peopleMechanisms

Paper

IECCMEXICOJul 31

Clonal Hematopoiesis in the Era of Precision Medicine: Molecular Mechanisms, Cardiovascular Implications, and Risk of Hematologic Malignancies

ReviewBlood and immune system

Paper

NatureOct 31

Clonal dynamics after allogeneic haematopoietic cell transplantation

Cohort study in peopleBlood and immune system

Paper

medRxivNov 21

Cost-effective and scalable clonal hematopoiesis assay provides insight into clonal dynamics

Preprint: cohort study of 456 peopleClonal hematopoiesis of indeterminate potential

Paper