What does the research say about multi-organ aging imbalance?

Multi-organ aging imbalance

There is 1 paper on multi-organ aging imbalance in aging research: 1 observational study in people. The newest story, Nov 12, 2026: “Uneven organ aging linked to higher death risk in UK cohort”.

Biomarker

1 paper studies it4 findings

1 new paper in 30 daysSee all 1 papers on multi-organ aging imbalance

“Higher multi-organ aging imbalance was independently associated with all-cause mortality (HR per 1-s.d. increase, 1.11; 95% CI, 1.09–1.13)”

Beyond accelerated aging: Multi-organ aging imbalance predicts adverse health outcomesResearch Square2026doi:10.21203/rs.3.rs-11629199/v1

Humans1

Associations

Frailty

upin humans1

1 study

Multi-organ aging imbalance is associated with frailty in humans (Analyses restricted to ELSA and CHARLS).
“In separate analyses restricted to ELSA and CHARLS, higher imbalance was associated with greater frailty burden and incident frailty.”
HumansAnalyses restricted to ELSA and CHARLS
Uneven organ aging linked to higher death risk in UK cohort
Research SquareNov 9, 2026Preprint

Multimorbidity transitions

upin humans1

1 study

Multi-organ aging imbalance is associated with multimorbidity transitions in humans (Adjusted for overall biological-age deviation, chronological age and sex) (Three multimorbidity transitions).
“six incident organ-disease outcomes and three multimorbidity transitions after adjustment for overall biological-age deviation, chronological age and sex.”
HumansAdjusted for overall biological-age deviation, chronological age and sexn = 221,599
Uneven organ aging linked to higher death risk in UK cohort
Research SquareNov 9, 2026Preprint

Incident organ disease

upin humans1

1 study

Multi-organ aging imbalance is associated with incident organ disease in humans (Adjusted for overall biological-age deviation, chronological age and sex) (Six incident organ-disease outcomes).
“Higher multi-organ aging imbalance was independently associated with all-cause mortality (HR per 1-s.d. increase, 1.11; 95% CI, 1.09–1.13), six incident organ-disease outcomes”
HumansAdjusted for overall biological-age deviation, chronological age and sexn = 221,599
Uneven organ aging linked to higher death risk in UK cohort
Research SquareNov 9, 2026Preprint

Mortality

upin humans1

1 study

Multi-organ aging imbalance is associated with mortality in humans (Adjusted for overall biological-age deviation, chronological age and sex) (HR per 1-s.d. increase, 1.11; 95% CI, 1.09–1.13).
“Higher multi-organ aging imbalance was independently associated with all-cause mortality (HR per 1-s.d. increase, 1.11; 95% CI, 1.09–1.13)”
HumansAdjusted for overall biological-age deviation, chronological age and sexper 1-s.d. increasen = 221,599
Uneven organ aging linked to higher death risk in UK cohort
Research SquareNov 9, 2026Preprint

Latest

1 paper in 12 months

Research SquareNov 10

Uneven organ aging linked to higher death risk in UK cohort

Higher imbalance was linked to greater mortality risk, with a relative-risk measure called a hazard ratio of 1.11 per standard-deviation increase.Higher imbalance was linked to greater mortality risk, with a relative-risk measure called a hazard ratio of 1.11 per standard-deviation increase.

Preprint: cohort · 221,599 peopleBiomarkers

Paper

Multi-organ aging imbalance

Associations

Latest

Uneven organ aging linked to higher death risk in UK cohort

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