Microglial reparative gene expression

Biomarker

1 paper studies it2 findings

1 new paper in 30 daysSee all 1

  • Animals1

Interventions

2

CCL11

downin mouse cells1

1 study
  1. CCL11 decreases microglial reparative gene expression in mouse cells.

    “recombinant CCL11 administration downregulated the expression of these 'reparative' genes”

    CellsICH-like injuryrecombinantprimary microglia

    Targeting a protein raises repair-linked gene activity in aged mice

    Neuroreport

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ANTI-CCL11 antibody

upin mice1

1 study
  1. ANTI-CCL11 antibody increases microglial reparative gene expression in mice.

    “sequestration of CCL11 in the circulation of aged mice prior to ICH upregulates the expression of microglial genes linked to pro-phagocytic, antioxidative, and anti-inflammatory signaling.”

    Animalsadministered before experimental intracerebral hemorrhagemicroglia from the ipsilateral brain hemispheremales

    Targeting a protein raises repair-linked gene activity in aged mice

    Neuroreport

More on ANTI-CCL11 antibody

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Neuroreport

Targeting a protein raises repair-linked gene activity in aged mice

In 18-month-old male mice, an antibody given before an experimental brain bleed raised gene activity linked to cellular cleanup and inflammation control.In 18-month-old male mice, an antibody given before an experimental brain bleed raised gene activity linked to cellular cleanup and inflammation control.

Mouse studyInterventions