Methylation burden score

Leukocyte is associated with methylation burden score in humans (36.4%).

“Composition change alone explained 36.4% and 63.9% of the variance in burden change in the two cohorts, with concordant lymphoid-to-myeloid direction.”

Humansreference-based deconvolution in Danish cohortwhole blood120-month intervaln = 86

Leukocyte Composition Change Accounts for Most Apparent Ten-Year DNA Methylation Drift in Blood: A Two-Cohort Longitudinal Analysis

Research Square·19 Aug 2026Preprint