Metabolomic age acceleration

1. Metabolomic age acceleration is associated with risk of a higher frailty score in humans (10% increased risk per standard deviation (∼5 years)).

   “10% increased risk of a higher frailty score in fully adjusted models.”

   Humansfully adjusted modelsEach standard deviation higher metabolomic age acceleration (∼5 years)

   Assessment of ageing using global mass-spectrometry based metabolomics: A cross-cohort longitudinal study in the UK and Ireland

   medRxiv·10 Feb 2026Preprint

1. Metabolomic age acceleration is associated with mild cognitive impairment in humans (27% higher risk per standard deviation (∼5 years)).

   “Each standard deviation higher metabolomic age acceleration (∼5 years) was associated with 43% higher mortality risk, 27% higher risk of mild cognitive impairment”

   Humansfully adjusted modelsEach standard deviation higher metabolomic age acceleration (∼5 years)

   Assessment of ageing using global mass-spectrometry based metabolomics: A cross-cohort longitudinal study in the UK and Ireland

   medRxiv·10 Feb 2026Preprint

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1. Metabolomic age acceleration is associated with mortality in humans (43% higher mortality risk per standard deviation (∼5 years)).

   “Each standard deviation higher metabolomic age acceleration (∼5 years) was associated with 43% higher mortality risk”

   Humansfully adjusted modelsEach standard deviation higher metabolomic age acceleration (∼5 years)

   Assessment of ageing using global mass-spectrometry based metabolomics: A cross-cohort longitudinal study in the UK and Ireland

   medRxiv·10 Feb 2026Preprint

1. Metabolomic age acceleration is associated with metabolomic age acceleration at another study visit in humans (r > 0.6).

   “Metabolomic age acceleration was strongly correlated between study visits ( r > 0.6).”

   Humansbetween study visits

   Assessment of ageing using global mass-spectrometry based metabolomics: A cross-cohort longitudinal study in the UK and Ireland

   medRxiv·10 Feb 2026Preprint

More on Metabolomic age acceleration at another study visit