Longitudinal effects in brain age gap

anatomical covariance matrix eigenspectrum predicts longitudinal effects in brain age gap in silico (83.2% vs 7.7%).

“83.2% with the leading eigenvector versus a maximal value of 7.7% for any brain region”

In silicoin amyloid positive vs amyloid negative subcohorts

Covariance Eigenspace Provides Latent Attribution of Longitudinal Effects in Brain Age Gap

arXiv·Sep 30, 2026Preprint