Long-chain (24C) CER[NdS] species

age decreases long-chain (24C) CER[NdS] species in humans (-3.9%, p < 0.0001).

“Notably, CER[NdS] species shifted towards shorter (16oC) acyl chains (+2.23%, p = 0.01) and away from longer (24oC) chains (-3.9%, p < 0.0001).”

Humansin adults with dry, eczema-prone skinstratum corneumn = 58

The Impact of Age on the Lipidomic Profile of the Stratum Corneum and Associated Effects on Structure, Function and Overall Skin Health in Adults Predisposed to Atopic Dermatitis

Experimental dermatology·1 Dec 2025