Lifestyle for Brain Health index

1. Lifestyle for Brain Health index has no effect on hippocampal volume in humans.

   “while no effects on hippocampal volume were detected.”

   Humansmean: 6.6 yearsn = 1,581

   The impact of socioeconomic status and lifestyle on cognitive aging and brain health: results from the LIFE-Adult-Study

   Alzheimer's research & therapy·24 Mar 2026

More on Hippocampal volume

1. Lifestyle for Brain Health index increases white matter hyperintensities in humans (b = 0.02, 95% CI: 0.003; 0.03).

   “Detrimental changes in LIBRA were linked to higher WMH volume at follow-up (b = 0.02, 95% CI: 0.003; 0.03)”

   Humansdetrimental changes in LIBRAmean: 6.6 yearsn = 1,581

   The impact of socioeconomic status and lifestyle on cognitive aging and brain health: results from the LIFE-Adult-Study

   Alzheimer's research & therapy·24 Mar 2026

More on White matter hyperintensities

1. Lifestyle for Brain Health index impairs cognitive function in humans (b = –0.007, 95% CI: –0.01, –0.001).

   “higher squared LIBRA-scores predicted lower cognitive performance (b = –0.007, 95% CI: –0.01, –0.001).”

   Humanssquared LIBRA-scoresmean: 6.6 yearsn = 1,581

   The impact of socioeconomic status and lifestyle on cognitive aging and brain health: results from the LIFE-Adult-Study

   Alzheimer's research & therapy·24 Mar 2026