LeDXA biological-age gap

1. Hormone replacement therapy is associated with LeDXA biological-age gap in humans.

   “The gap also decreased in women after starting hormone-replacement therapy”

   HumansAfter starting hormone-replacement therapyfemales

   Self-supervised DXA representations encode multi-system disease risk, biological aging and heritability

   arXiv (Cornell University)·3 Aug 2026Preprint

More on Hormone replacement therapy

1. LeDXA biological-age gap is associated with mortality in humans (45% higher mortality hazard in the oldest-appearing quartile).

   “the biological-age gap tracked broader disease burden and a 45% higher mortality hazard in the oldest-appearing quartile.”

   HumansOldest-appearing quartile

   Self-supervised DXA representations encode multi-system disease risk, biological aging and heritability

   arXiv (Cornell University)·3 Aug 2026Preprint