Iron fragility index

1. Iron fragility index decreases FEV1 in humans (beta = -0.028, 95% CI -0.053 to -0.004).

   “higher IFI was associated with lower overall FEV1 (beta = -0.028, 95% confidence interval [CI] -0.053 to -0.004)”

   Humansasthman = 532

   Dynamic iron dysregulation, lung function, and functional deterioration in adults aged 50 years and older with asthma: a longitudinal cohort study

   Research Square·28 Aug 2026Preprint

More on FEV1

1. Iron fragility index raises the risk of severe ADL deterioration in humans (HR = 1.19, 95% CI 1.03 to 1.37).

   “IFI showed a similar association (HR = 1.19, 95% CI 1.03 to 1.37)”

   Humansasthma

   Dynamic iron dysregulation, lung function, and functional deterioration in adults aged 50 years and older with asthma: a longitudinal cohort study

   Research Square·28 Aug 2026Preprint