iPRS-DEM
Biomarker1 paper4 findings
- Humans1
Associations
4Mortality
upin humans1HR 1.33
1 study
Mortality
upin humans1HR 1.33
iPRS-DEM raises the risk of mortality in humans (HR 1.33, 95% CI 1.15-1.54).
Humanspoor vs favorable profiles58% femalesn = 14,333
Dementia polygenic score links to dementia, disability, and death · medRxiv : the preprint server for health sciences · 11 Sep 2026 · Preprint
Disability
upin humans1HR 1.43
1 study
Disability
upin humans1HR 1.43
iPRS-DEM raises the risk of disability in humans (HR 1.43, 95% CI 1.14-1.79).
Humanspoor vs favorable profiles58% femalesn = 14,333
Dementia polygenic score links to dementia, disability, and death · medRxiv : the preprint server for health sciences · 11 Sep 2026 · Preprint
Dementia
upin humans1HR 1.58
1 study
Dementia
upin humans1HR 1.58
iPRS-DEM raises the risk of dementia in humans (HR 1.58, 95% CI 1.21-2.05).
Humanspoor vs favorable profiles58% femalesn = 14,333
Dementia polygenic score links to dementia, disability, and death · medRxiv : the preprint server for health sciences · 11 Sep 2026 · Preprint
Composite of dementia, disability, or death
upin humans1HR 1.43
1 study
Composite of dementia, disability, or death
upin humans1HR 1.43
iPRS-DEM raises the risk of composite of dementia, disability, or death in humans (HR 1.43, 95% CI 1.26-1.63).
Humanspoor vs favorable profile58% femalesn = 14,333
Dementia polygenic score links to dementia, disability, and death · medRxiv : the preprint server for health sciences · 11 Sep 2026 · Preprint
Latest
1Dementia polygenic score links to dementia, disability, and death
Compared with favorable profiles, poor dementia polygenic profiles were associated with a 1.43 hazard ratio for a composite of dementia, disability…Compared with favorable profiles, poor dementia polygenic profiles were associated with a 1.43 hazard ratio for a composite of dementia, disability, or death.