Insulin-to-proinsulin ratio

1. Anakinra has no effect on insulin-to-proinsulin ratio in mice.

   “short-term, systemic IL-1R1 antagonism failed to restore enzyme expression or insulin maturation in aged mice.”

   Animalsshort-term

   Mechanisms and Consequences of IL-1β-Mediated Changes in β-Cell Function

   ADA Scientific Sessions 2026 abstract·5 Jun 2026

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1. IL-1β has no effect on insulin-to-proinsulin ratio in mice.

   “immune cell-specific IL-1β deletion did not show an improvement in the insulin-to-proinsulin ratio.”

   Animalsimmune cell-specific deletion

   Mechanisms and Consequences of IL-1β-Mediated Changes in β-Cell Function

   ADA Scientific Sessions 2026 abstract·5 Jun 2026

More on IL-1β