INK4/ARF locus expression
1 paper studies it1 finding
- Cells1
Upstream
1SIRT2
downin mouse cells1
1 study
SIRT2
downin mouse cells1
SIRT2 decreases INK4/ARF locus expression in mouse cells.
“SIRT2 depletion not only upregulated elements of the INK4/ARF locus, which in turn had an antiproliferative effect”
Cellsshown by SIRT2 depletionmouse embryonic fibroblast
SIRT2 is required for efficient reprogramming of mouse embryonic fibroblasts toward pluripotency
Cell death & disease
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Cell Death & Disease
SIRT2 is required for efficient reprogramming of mouse embryonic fibroblasts toward pluripotency
Experiments in mouse cellsMechanisms