AgingResearch.NewsJoin free

Inducible granzyme B

There are 2 papers on inducible granzyme B in aging research: 2 trials in people.

Biomarker

2 papers study it3 findings

See all 2

  • Human trial2

Interventions

1

High-dose split-virus influenza vaccine

upin humans1no changein humans1

1 study

  1. High-dose split-virus influenza vaccine increases inducible granzyme B in humans (std. β 0.072, 95% CI 0.047 to 0.097).

    “HD vaccine was associated with significantly higher levels [0.072 (0.047, 0.097”

    Human trial20 weeksn = 582

    Key Determinants of Cell-Mediated Immune Responses: A Randomized Trial of High Dose Vs. Standard Dose Split-Virus Influenza Vaccine in Older Adults

    Frontiers in aging

  2. High-dose split-virus influenza vaccine showed no clear effect on inducible granzyme B in humans.

    “Overall, HD-SVV amplified the IL-10 response consistent with enhanced antibody responses, with little effect on the iGrB response relative to SD-SVV in either younger or older adults.”

    Human trialn = 582

    Key Determinants of Cell-Mediated Immune Responses: A Randomized Trial of High Dose Vs. Standard Dose Split-Virus Influenza Vaccine in Older Adults

    Frontiers in aging

More on High-dose split-virus influenza vaccine

Upstream

1

Cytomegalovirus infection

downin humans1

1 study

  1. Cytomegalovirus infection decreases inducible granzyme B in humans.

    “CMV seropositive older adults had an impaired iGrB response to influenza virus-challenge, regardless of vaccine dose.”

    Human trialPBMCs challenged ex vivo with live influenza virus

    Influenza vaccine-mediated protection in older adults: Impact of influenza infection, cytomegalovirus serostatus and vaccine dosage

    Experimental gerontology

More on Cytomegalovirus infection

Latest

Related