Advanced Science
Brain scan model flags Alzheimer’s risk in Chinese adults
Without retraining, the model scored 0.913 for distinguishing Alzheimer’s from normal cognition and identified 95.2% of Alzheimer’s scans in the Chinese cohort.Without retraining, the model scored 0.913 for distinguishing Alzheimer’s from normal cognition and identified 95.2% of Alzheimer’s scans in the Chinese cohort.
Cohort · 474 peopleAlzheimer's disease
Who was studied474 Chinese adults without Alzheimer’s disease at baseline, 167-month follow-up
What changedAlzheimer’s developed in 52 of the 177 high-risk participants versus 8 of the 297 low-risk participants
The catchThe high-risk cutoff was optimized on this cohort, risking overly favorable prediction estimates