IDH2 mRNA expression

1. IDH2 mRNA expression is associated with metabolic syndrome in humans (6.3-fold higher odds per 10% decrease in transcription).

   “for every 10% decrease in IDH1 and IDH2 transcription, the odds of developing obesity-associated MetS increases by 4.9- and 6.3-fold, respectively.”

   HumansPer 10% decrease in IDH2 transcription; obesity-associated metabolic syndromeperipheral whole blood

   Differential NADP-Dependent Isocitrate Dehydrogenases Expression in Metabolically Healthy Obesity vs Metabolic Syndrome: A Probable Predictive Biomarker for Metabolic Deterioration

   The journal of applied laboratory medicine·15 Aug 2025

2. Metabolic syndrome is associated with IDH2 mRNA expression in humans.

   “IDH2 was more deficient in MetS than MHO, and both were lower than controls.”

   HumansMetabolic syndrome compared with metabolically healthy obesity and healthy controlsperipheral whole blood

   Differential NADP-Dependent Isocitrate Dehydrogenases Expression in Metabolically Healthy Obesity vs Metabolic Syndrome: A Probable Predictive Biomarker for Metabolic Deterioration

   The journal of applied laboratory medicine·15 Aug 2025

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