Histone succinylation

Exceptional longevity is associated with histone succinylation in humans.

“histone succinylation was significantly elevated in the OPEL group compared to both young and OPUS cohorts”

Humansin offspring of long-lived individuals (OPEL) compared to both young and OPUS cohortsB-cells

Preliminary Evidence for Increased Histone Succinylation as a Potential Epigenetic Marker for Longevity

Aging cell·23 Dec 2025