Hippocampal insulin response

1. Prediabetes risk cluster is linked with lower hippocampal insulin response in humans (women in high-risk clusters compared with men) (estimate 0.39, p=0.02).

   “women in high-risk Tübingen prediabetes clusters also showed lower hippocampal insulin responsiveness than men (sex × cluster type: estimate 0.39, p=0.02)”

   Humanswomen in high-risk clusters compared with menhippocampusfemales

   Unhealthy fat distribution as a sex-specific predictor of declining hippocampus insulin sensitivity

   Diabetologia·Jul 3, 2026

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1. Waist-to-hip ratio predicts hippocampal insulin response in humans (interaction with age and sex; effects remained after adjusting for BMI) (interaction estimate 0.233, p=0.010).

   “In women, higher WHR, VAT and IHL were predictors of lower hippocampal insulin responsiveness with increasing age.”

   Humansinteraction with age and sex; effects remained after adjusting for BMIhippocampusfemales

   Unhealthy fat distribution as a sex-specific predictor of declining hippocampus insulin sensitivity

   Diabetologia·Jul 3, 2026

More on Waist-to-hip ratio

1. Fasting plasma glucose predicts hippocampal insulin response in humans (independently of sex, with increasing age) (estimate 0.533, p=0.016).

   “Fasting plasma glucose levels predicted lower hippocampal insulin response with age independently of sex (estimate 0.533, p=0.016).”

   Humansindependently of sex, with increasing agehippocampus

   Unhealthy fat distribution as a sex-specific predictor of declining hippocampus insulin sensitivity

   Diabetologia·Jul 3, 2026

More on Fasting plasma glucose